If left untreated, it can lead to serious health problems such as heart disease, stroke, and kidney failure. doi: 10.1016/j.maturitas.2010.06.001.High blood pressure, also known as hypertension, is a common condition that affects millions of people worldwide. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: A randomised controlled trial. Effect of garlic on blood pressure, serum cholesterol and immunity: Updated meta-analyses and review. A systematic review and meta-analysis on the effects of garlic preparations on blood pressure in individuals with hypertension. Rohner A, Ried K, Sobenin IA, Bucher HC, Nordmann AJ. Effects of garlic on blood pressure in patients with and without systolic hypertension: A meta-analysis. Reinhart KM, Coleman CI, Teevan C, Vachhani P, White CM. Effect of garlic on blood pressure: A systematic review and meta-analysis. Ried K, Frank OR, Stocks NP, Fakler P, Sullivan T., 1, Ried K, Frank OR, Stocks NP, Fakler P, Sullivan T. Thus, Kyolic aged garlic extract is considered to be highly tolerable with a high safety profile either as a stand-alone or adjunctive anti-hypertensive treatment, with multiple benefits for cardiovascular health.Īged garlic extract arterial stiffness blood pressure gut microbiome hypertension meta-analysis pulse wave velocity. Furthermore, Kyolic aged garlic extract significantly lowered central blood pressure, pulse pressure, pulse wave velocity and arterial stiffness, and improved the gut microbiota, evidenced by higher microbial richness and diversity, with a marked increase in the numbers of Lactobacillus and Clostridia species found following 3 months of supplementation. Additionally, this review summarises new evidence for the vitamin B12 status playing an important role in the responsiveness of blood pressure to garlic. This reduction in blood pressure was associated with a 16-40% reduction in the risk of suffering from cardiovascular events. The meta-analysis of 12 trials and 553 hypertensive participants confirmed that garlic supplements lower systolic blood pressure (SBP) by an average of 8.3☑.9 mmHg and diastolic blood pressure (DBP, n=8 trials, n=374 subjects) by 5.5☑.9 mmHg, similarly to standard anti-hypertensive medications. We searched online electronic databases, including PubMed and Google Scholar for randomised controlled trials (RCTs) published between 1955 and December, 2018 examining the effects of garlic on high blood pressure. In addition, we summarise the findings of recent clinical trials investigating the effects of Kyolic aged garlic extract on arterial stiffness, and gut microbiota in hypertensive subjects. This article systematically reviews previously published trials investigating the effects of garlic on blood pressure, and provides an updated meta-analysis of hypertensive participants. In addition, the prebiotic properties in garlic increase gut microbial richness and diversity. Kyolic garlic has also shown promise in improving cardiovascular health by reducing arterial stiffness, elevated cholesterol levels and blood 'stickiness'. Garlic supplements have shown effectiveness in reducing blood pressure in hypertensive patients, similarly to first-line standard anti-hypertensive medications.
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